Friday, January 27, 2023

Is The Keto Diet Good For Arthritis

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The Ketogenic Diet And Inflammation

Many types of pain and painful or progressive conditions involve chronic inflammation. As noted above, several mechanistic threads support the hypothesis that a ketogenic diet will reduce inflammation. Compared to glucose metabolism, ketone metabolism produces fewer reactive oxygen species – which are known to contribute to inflammation. A ketolytic metabolism produces fewer free radicals and reactive oxygen species through affecting the mitochondrial co-enzyme Q couple and the cytoplasmic glutathione couple.Exogenously applied ketones reduce reactive oxygen species in vitro– and in vivo. Therefore the ketone-based metabolism of a ketogenic diet should guard against inflammation.

Data suggesting positive effects of a ketogenic diet itself on inflammation or associated inflammatory processes have been accumulating recently. In rodents, ketogenic diets reduce reactive oxygen species in the brain and reduce central inflammation and reactive oxygen species in a model of multiple sclerosis. Two clinical papers have found that ketogenic diet feeding of 12 weeks to 6 months reduced signs of liver inflammation in obese patients with nonalcoholic fatty liver disease ., Unfortunately, basic research into non-alcoholic fatty liver disease has been hampered by species differences between mice and humans in their hepatic reaction to ketogenic diets.

The Keto Diet: How It Effects These 5 Types Of Arthritis

The ketogenic diet is a high-fat, low-carb, and moderate protein diet. It has a range of proven health benefits which include alleviating the symptoms of some types of arthritis. The purpose of the keto diet is to enter into a state where your body burns fats instead of carbohydrates for fuel.

There are several macronutrient variations of the ketogenic diet. However, a fairly common breakdown will comprise of the following:

  • 20-30% of calories from protein
  • 70-80% of calories from healthy fats
  • 5% or less of calories from carbohydrates

When you eat a carbohydrate rich diet your body converts those carbs into glucose. This spikes your blood sugar levels, which in turn signals your body to create insulin. The insulin hormone carries glucose to your cells, and your cells then use that glucose for energy. This is an insulin spike

As long as you keep eating carbohydrates, your body will keep turning them into sugar which it then burns for energy. But when you severely limit your carbohydrate intake, you force your body to burn fat. When this happens, your body converts fatty acids into ketones, placing your body into a metabolic state known as ketosis. By following a keto diet, your body will become keto-adapted, i.e. more efficient at burning fat. This is the essence of the ketogenic diet and is important if you suffer from arthritis.

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Maintaining A Healthy Weight

Being overweight can put extra pressure on the joints, and excess fat stores in the body can cause further inflammation. Maintaining a healthy weight can lessen the symptoms of osteoarthritis.

Keeping to a healthy weight can be difficult for some people, especially those who have a medical condition that reduces their mobility, such as osteoarthritis. A doctor or dietitian will be able to provide advice.

Including specific foods in the diet can strengthen the bones, muscles, and joints and help the body to fight inflammation and disease.

People with osteoarthritis can try adding the following eight foods to their diet to ease their symptoms:

My Rheumatoid Arthritis Experience

Rheumatoid Arthritis Diet: Is Keto the Way?

My first taste of joint pain was shortly after I started a job in road construction. I couldnt stand in one place for more than a few minutes. The pain in my knees & lower back was excruciating, almost brought me to tears. At the time, I thought it was from working long shifts where I was standing for 12-14 hours. In grade 11 I was diagnosed with Spondylolisthesis so thought this pain could be related. The pain persisted for 3 months and my only recourse was taking pain killers or having a few drinks. Eventually, I went to the doctor and he said you likely suffer from some form of arthritis. My joint issues took a backseat as I experienced new symptoms: blood in my poop, night sweats, and unformed bowel movements. I was referred to a GI Doc and this was the beginning of a diagnosis of severe Crohns Disease & Ulcerative Colitis. I experienced flare up of my gut symptoms and other times it was my joints. My GP sent me for more tests in regards to the joint pain. When the tests came back he concluded that I suffered from Rheumatoid Arthritis. Now, I could say I suffered from 3 autoimmune conditions.. thats 1 more than my grandma who had UC & RA. With all these initials I felt like a real professional CD, UC, & now RA. Gratefully I was able to overcome all 3 of these issues.

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Chronic Inflammation And Rheumatoid Arthritis

What do autoimmune disorders like rheumatoid arthritis, multiple sclerosis, and celiac disease have in common? Chronic, systemic inflammation.

Chronic inflammation isnt the same as acute inflammation. Acute inflammation is how your body recovers from exercise, fights off viruses and bacteria, and heals wounds. Acute inflammation is normal.

Chronic inflammation, on the other hand, occurs when your immune system is always on high alert and starts to attack molecules and tissues it shouldnt attack.

And this can cause major damage.

Chronic inflammation underlies most chronic disease: diabetes, heart disease, cancer, Alzheimers, autoimmune conditions like rheumatoid arthritis.

Many, many things cause chronic inflammation. Heres a partial list:

  • Tobacco smoke
  • Stress

So no, theres no easy button for reducing inflammation. Its a lifestyle commitment.

And of all the lifestyle factors, diet is the one most within your control. Its also one of the most impactful changes you can make.

Take the ketogenic diet. The keto diet is best known for weight loss, but did you know its anti-inflammatory too?

This Is Where The Ketogenic Diet Comes In

By significantly reducing your carbohydrate intake, you can significantly reduce the amount of inflammation in your body. In fact, a 2010 study published in The American Journal of Clinical Nutrition, found a direct link between people with a high carb intake and inflammatory diseases. This is because a high carb diet means your blood sugar levels remain elevated and lead to a state called hyperglycaemia. This state is highly-inflammatory. The keto diet is low-carb so suppresses your blood sugar levels. Whats more, the keto diet is high in healthy fats, which helps to regulate both your blood sugar and insulin levels.

Another beneficial aspect of the keto diet is that ketones are a much cleaner energy source in comparison to sugar. As a result of using ketones, your cells create fewer reactive oxygen species than they would from glucose. ROS are a byproduct of energy metabolism. Some ROS are a good thing but excess ROS causes oxidative stress which increases inflammation.

The ROS reducing effects of ketones has actually been measured in a laboratory setting. In a 2004 study, researchers fed mice either a standard diet or a ketogenic diet. They then measured ROS levels and mitochondrial respiration. In the ketogenic group, not only were ROS reduced, but the maximum mitochondrial respiration nearly doubled. It means that a keto diet offers you more energy at the same time as creating less inflammation.

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Diet Types To Consider

Some people tout certain diets as being beneficial for health conditions. Here we take a look at several popular diets and how they may affect psoriasis and psoriatic arthritis.

Note that the approach of these diets vary widely some even provide conflicting guidance. As well, there is limited evidence that these diets actually improve psoriatic arthritis.

Reduction In Ra Symptoms And Pain

This is how Keto can help with arthritis/inflammation!

A clinical trial study showed that ketogenic diet reduced morning stiffness in rheumatoid arthritis patients .

Fats are responsible for an improvement in RA symptoms and may cause a reduction in drug usage .

Consumption of n-3-fatty acids in the diet helps alters the biochemical response in the body and may provide benefits to RA patients .

Another clinical trial involving thirteen rheumatoid arthritis patients conducted by Fraser DA et. al. , concluded that there were no benefits of a ketogenic diet on disease activity and immune response changes .

In animal studies, ketogenic diet shows great potential for reducing pain along with inflammation . Pain forms a major symptom of rheumatoid arthritis and the use of painkillers is common in RA patients.

If ketogenic diet could reduce pain, then it could drastically reduce the use of painkillers.

What does this mean? Ketogenic diet reduces morning stiffness experienced by RA patients. It also has pain relieving action which can reduce the use of pain killers.

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Why Keto Is A Short

The goal of the keto diet is to get your body into a state of ketosis, which is when your body doesnt have enough carbohydrates to burn for energy, so it starts to burn fat instead. If you can get through the first three days to get into ketosis, it can help to shut down appetite and control cravings, says Sandon. From a weight loss perspective, it can be effective in the short term. But eventually you do get hungry, and you need to get back to eating regular food again.

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Role Of Diet In Rheumatoid Arthritis: Does Food Matter

During my diagnosis doctors said it didnt matter what I ate. I think weve come a long way in 12+ years: common sense and science are prevailing. I know its confusing with disinformation and too many choices. We will combine science with anecdotal experiences. We can start off by looking at the foods & factors that negatively affect RA.

RA Trigger Foods & Factors:

  • Obesity is associated with RA+
  • 2/3 of people with RA are obese or overweight +

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However The Link Between Protein Consumption And Gout Is Far From Conclusive

Rheumatoid Arthritis Diet

In a 2004 study published in The New England Journal of Medicine, researchers linked meat and seafood consumption to increased gout risk. But a more controlled study was conducted in 2014. Publishing their results on the American College of Rheumatology website, researchers found that six months of a high-protein, low-carb diet reduced uric acid levels in 74 overweight or obese participants. Another study published in 2013 found that vegans have higher uric acid levels than meat eaters. Overall, these studies suggests that meat probably isnt the problem when it comes to gout.

Sugar is the more likely culprit in this equation. Fructose, the sugar found in fruit and corn syrup, is now known to increase uric acid production. At the same time, fructose also prevents uric acid clearance in the body. This is because when your liver becomes loaded with fructose it can interfere with protein metabolism and deplete ATP . When your ATP drops, your uric acid production increases.

Whats more, when you ingest high levels of sugar, you become insulin resistance . It means that you have high levels of insulin in your body. And high levels of circulating insulin decreases uric acid clearance.

Reducing your sugar intake by reducing your carbohydrate intake is therefore an effective way of alleviating your gout symptoms.

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Chronic Inflammation & Autoimmunity In Ra

RA involves the accumulation of inflammation in and around the joints caused by a chronically elevated immune response. A typically beneficial and protective mechanism of the immune system, in this case, turns into a damaging force.

A commonly prescribed treatment is pain medication and immune system-suppressing drugs. This is in an attempt to calm the immune system and decrease the perception of pain. The issue here, though, is that the underlying issues are not addressed in any way. Consequently, many people do not feel any improvement while using these therapies.

This is why I would like to express my thoughts on a rheumatoid arthritis nutrition template that may be used as an alternative or complementary therapy.

Keto Diet And Arthritis: Stopping Pain At The Source

In conventional medicine, the first-line treatments for degenerative arthritis are anti-inflammatory and painkilling drugs. Many doctors also advocate for joint replacement surgery.

Of course, with the opiod epidemic in full swing, we understand the risks associated with painkillers. In addition, there are also significant risks associated with surgical treatment, including infection, rejection or implant illness, and a potentially long recovery.

However, new research shows there may be safer and better ways to prevent and treat OA: Your diet!

Weve long known that free radicals and the oxidative stress caused by these compounds plays an important role in most chronic diseases. And arthritis is no exception

A recent study, published in Pain Medicine, evaluated the levels of oxidative stress in test subjects and how these levels are correlated with painful symptoms. The researchers already knew that lower oxidative stress is associated with less pain.1

But they also sought to discover which diet could reduce oxidative stress the most and therefore provide pain-relief for those suffering degenerative arthritis.

The researchersexamined a group of subjects over the age of 65 all of whom experienced arthritic pain and damage in their knees. The subjects were split into three groups and prescribed a diet. One group followed a low-carb diet. Another followed a low-fat diet. And the third group ate as they normally would.

Lead author of the study, Dr. Robert Sorge, said:

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Seven Days Fasting Followed By Vegan Diet

Fraser et al. observed that subtotal fasting where patients were allowed to have limited amount of vitamin and mineral supplementation, carbohydrate, and energy in form of vegetable juice decreased CD4+ lymphocyte activation and numbers. Activation of CD4+ T cell and further differentiation to Th1 and Th17 lineages are shown to be responsible for progression of RA . Thus, decreased T cell activation owing to 710 day fasting suggests a transient immunosuppression, thereby suppressing RA . Michalsen et al. have also shown beneficial effect of fasting on clinical improvement in RA patients as compared to non-fasting group, although the results were independent of alterations in intestinal flora .

A fasting of 710days with partial nutrient intake of vegetable broth, herbal teas, parsley, garlic, and decoction of potatoes juice extracts from carrots, beets, and celery and a controlled daily energy intake followed by 1year of a vegan diet as compared to omnivorous diet was studied in different trials . Together these studies observed remarkable decrease in swollen and tender joints, pain, erythrocyte sedimentation rate , and C-reactive protein .

What To Avoid In A Ketogenic Diet

Rheumatoid arthritis RA, keto and diet

A ketogenic diet requires a person to avoid carbohydrates and sugary foods. One must refrain from sweets, cakes, candies, sodas, pasta, rice, chapati, gravies, sauce etc .

Fruits rich in carbohydrates like apple, blueberries, banana, mango, pineapple etc., must be avoided .

Vegetables like potatoes, beans, grains, peas, onions, corn etc., must also be avoided in a ketogenic diet .

However, a very small amount of carbohydrates can be included in the diet .

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Overview Of Therapeutic Options For Ra

There are numerous other holistic ways of improving rheumatoid arthritis symptoms including:

  • Reducing stress
  • Consuming foods and herbs high in anti-oxidants
  • Supplementing the diet with omega-3s
  • Supplementing with Vitamin D and K2
  • Several other considerations, as you can read about in this article.

In addition to the recommendations above, I believe that there is still another way to help control many of the symptoms and pain that RA patients deal with on a daily basis. Much of the pain that RA patients feel comes from inflammation.

If inflammation can be controlled, then it follows that pain could also be controlled. To a large degree, your nutrition plays a role in inflammation levels in the body. This is why it is possible to design an effective rheumatoid arthritis diet. In particular, a ketogenic nutrition plan may be able to provide several benefits.

A ketogenic diet may be an effective rheumatoid arthritis diet not only by helping control weight through accelerated fat loss but by also providing a substantial reduction in inflammation levels.

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