What Happens When You Get An Injection
The doctor, nurse, or other health professional will use an alcohol or iodine-based cleaning solution to clean the area of your skin where you’ll get the shot. After that, they’ll put a numbing lotion or spray on that spot. Then you’ll get the shot. You should only feel a little pain. Afterward, you’ll wear a bandage over the injection site.
If the shot is going into a joint that has too much fluid, your doctor will first use a separate syringe and needle to draw out the extra fluid.
The effects of your shot can last up to several months before it wears off.
Though it depends on your condition, your doctor will likely limit how often you get a cortisone shot to every 6 weeks and no more than four times a year.
If You’ve Had Repeated Injections In The Same Spot
Because cortisone shots can lead to slow tissue and cartilage damage, it is wise to avoid injecting the same area again and again.
“Getting cortisone injections frequently to the same joint can be highly detrimental, as frequent injections in the same joint can damage it, as well as the surrounding soft tissue,” Kathryn cautions. “This may lead to the softening of the cartilage in joints or weakening of the tendons.
You Need To Tell Your Doctor About Your Medical History
Overall, cortisone shots are very safe. However, some medical diseases such as diabetes, cancer, or HIV infection can interact with cortisone. So you should tell your doctor. Also, if you are taking a blood thinner such as Warfarin, you may need to stop the medication for a short time. So, Warfarin and cortisone injections could increase your risk of bleeding.
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A Positive Effect On Joint Pain May Also Be Associated With Accelerated Joint Destruction
This is what research says about it:
- Research: Cortisone works well for some but not for others and no one seems to be able to identify why:
- From the journal Seminars in Arthritis & Rheumatism: Previous research has not identified reliable predictors of response to intraarticular corticosteroid injections, a widely practiced intervention in knee and hip osteoarthritis. Further studies are required if this question is to be answered.
What Is A Cortisone Shot

If you have arthritis, you might have considered a cortisone shot as part of your treatment plan. Also called âcorticosteroid,â âsteroid shot,â and a human-made version of the hormone cortisol, these shots aren’t pain relievers. Cortisone is a type of steroid, a drug that lowers inflammation, which is something that can lead to less pain.
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Considering That The Use Of Corticosteroids May Be Contraindicated In Some Patients And May Be Associated With The Risk Of Tendon Rupture We Suggest The Use Of Prp In Place Of Corticosteroid
A May 2021 paper in the Journal of Orthopaedic Surgery and Research set out to examine the contradictions found in published research over the comparative outcomes of cortisone versus PRP injections for the treatment of rotator cuff tendinopathy. Here are the learning points of this research:
- Studies evaluating the role of both corticosteroids and platelet-rich plasma in the treatment of rotator cuff tendinopathies have been contradicting.
- In this paper, patients received PRP or corticosteroids.
- The doctors then compared structural and clinical changes in rotator cuff muscles after corticosteroids and PRP injections.
Findings:
- During three months of follow-up, pain improvement was significantly better within the PRP group.
- Regarding the range of motion, the PRP group had significant improvement in adduction and external rotation
Prolotherapy Brings Oxygen To The Joint To Help Provide Healing Cells Energy And A Clean Safe Work Environment
In a 2017 stem cell study Dr. Ming Pei of West Virginia University publishing in the medical journal Biomaterials suggests that while adult stem cells are a promising cell source for cartilage regeneration, they have a hard time in a harsh joint environment when hypoxia and inflammation have created a toxic soup for the stem cells to work in. As noted above healing cells, like your native stem cells, like a clean, safe work environment. Chronic inflammation slowly and steadily brings about a low oxygen environment in joints because the body feels that diseased tissue will die in a low oxygen environment. Oxygen deprivation is designed to be a short-term drastic measure to healing a wound. But chronic inflammation means a slow strangulation of the joint
Sometimes we forget the cells of the body obtain their energy via aerobic metabolism. The primary substrates or substances that are needed for aerobic metabolism are oxygen and glucose. The body breathes to get oxygen and we eat to break down the food into sugar. Even if a person just eats protein, ultimately the body finds a way to break down the protein into individual amino acids and eventually into glucose. Without glucose, the cells and the body cannot live.
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What Are The Side Effects Of Cortisone Injections
As with any shot, there could be pain around the injection site for as long as 48 hours. For this, it is best to apply ice to the area to ease any discomfort. Immediately following the injection, you may experience a burning sensation, but that is normal. Some other side effects to keep an eye out for are infection, skin discoloration and nerve damage. However, those reactions are very rare.
Does Getting A Cortisone Shot For Arthritis Hurt
No doubt youve heard stories or have been warned that cortisone shots can be painful. Steroid shots are usually either mixed with a local anesthetic to help relieve pain or patients are given a local anesthetic first before the steroid shot is given. Some people feel minimal discomfort, while others feel intense pain its hard to explain why injections hurt some and not others, says Dr. Sufka. One thing is certain: being anxious doesnt help. Many times pain comes from tensing up muscles around the needle, he says. Dr. Sufka helps his patients his patients completely relax the area before the injection.
When Peggy Meyer, an osteoarthritis patient from North Carolina, was exploring her pain management options, she heard good and bad things about steroid shots but decided to go for it. I recall how I dreaded those shots initially, but the few seconds of discomfort is worth the relief it brings, Meyer says. Now, when my knee tells me its time for another shot, and I actually look forward to it.
Immediately icing the area after the injection can help relieve swelling and pain. You may feel fine right after the injection while the anesthetic is still effective, but as it wears off, you may actually feel pain that is worse than what you experienced before the procedure. This increased level of pain remember, a needle was just injected into your body should only last up to two days before things start to improve.
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A New Look At Steroid Injections For Knee And Hip Osteoarthritis
- By Robert H. Shmerling, MD,
Senior Faculty Editor, Harvard Health Publishing
Osteoarthritis is a common and potentially debilitating condition. Its a degenerative joint disease in which the smooth lining of cartilage becomes thinned and uneven, exposing the bone beneath.
Although osteoarthritis is tightly linked with aging, we now know there is more to it than age alone: genetics, weight, physical activity, and a number of other factors can conspire to make it more likely that someone will develop osteoarthritis while someone else wont. Osteoarthritis is the primary reason that more than a million joints are replaced each year in the US.
Treatments short of surgery can help but they dont always work well, dont cure the condition, and may be accompanied by side effects. Surgery is usually the last resort, reserved for people who have declining function, unrelenting pain, or both despite trying other treatments such as pain relieving, nonsteroidal anti-inflammatory drugs such as ibuprofen or naproxen , or injections of steroids or hyaluronic acid . Nonmedication approaches can also help, such as loss of excess weight, physical therapy, or use of a cane or brace.
Is A Cortisone Shot Safe During Pregnancy Or Breastfeeding
As a general rule, cortisone is safe in pregnancy. However, we dont like to inject cortisone in pregnant women unless absolutely needed. Also, we suggest to pregnant women that they speak to their obstetrician. Breast-feeding is not an issue as the amount of cortisone absorbed in breast milk from one injection is very small.
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What Are The Benefits Of Steroid Injections
Local steroid injections are less likely to cause serious side effects than other forms of steroid medications.
Steroid injections often ease inflammation in a joint so it can work better. They may keep you from needing to use oral steroids or higher doses of oral steroids, which could have stronger side effects.
How And When To Have Hydrocortisone Injections

A specialist doctor will usually give you your injection. This may be at your GP surgery.
If the injection is for pain, it may contain a local anaesthetic. You might also have a local anaesthetic by spray or injection to numb the skin before the hydrocortisone injection.
You can go home after the injection, but you may need to rest the area that was treated for a few days.
You may be able to have a hydrocortisone injection into the same joint up to 4 times in a year. The number of injections you need depends on the area being treated and how strong the dose is.
If you have arthritis, this type of treatment is only used when just a few joints are affected. Usually, no more than 3 joints are injected at a time.
The dose of hydrocortisone depends on the size of the joint. It can vary between 5mg and 50mg of hydrocortisone.
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How Are Cortisone Injections Into A Joint Given
The method of administering a cortisone injection into a joint is similar to that of soft-tissue injections. Betadine, however, is more commonly used for sterilization of the skin over the joint. This is an important precaution to prevent introducing infection into the joint. Furthermore, if there is an excessive amount of fluid within the joint, it often is removed first with a separate syringe and needle prior to injection of the cortisone. Removal of this joint fluid allows the doctor to examine the fluid and submit a sample to the laboratory for diagnosis. Removal also rapidly relieves pain by reducing the pressure in the fluid-filled joint. Finally, removal of fluid may allow the joint to heal more quickly. After a health care professional removes the fluid, he or she injects the cortisone medication into the joint, sometimes along with an anesthetic such as lidocaine or bupivacaine . Some health care professionals use an ultrasound to guide the needle into the exact location desired prior to injecting the cortisone into a joint .
What You Need To Know
- Arthritis is damage to the cartilage in joints. Shoulder arthritis occurs when the cartilage starts wearing down on the ball and/or socket sides of the shoulder joint.
- Symptoms of shoulder arthritis may include pain in the shoulder joint, stiffness and reduced range of motion.
- There are many nonoperative treatments for shoulder arthritis, including stretches, lifestyle modifications, application of ice or heat, and medication to control the pain.
- Surgical options, such as shoulder replacement, are available to treat shoulder arthritis if nonoperative treatments dont offer the desired relief.
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Cortisone Shots Less Effective Than Pt For Arthritis
People with stiff and aching knees due to arthritis get better relief from physical therapy than from cortisone injections, according to a one-year military study comparing the two treatments.
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A multi-disciplinary team of doctors reports in The New England Journal of Medicine that people who initially scored 107 on a 241-point scale measuring a combination of pain, stiffness and the ability to function saw their score improve by 65% when they underwent physical therapy and did home exercises.1
Thats significantly better than the 49% improvement seen among the volunteers who received repeated glucocorticoid injections.
Physical therapy provided relief that was just as rapid as steroid injections did and, as a matter of fact, physical therapy relief was probably quicker, chief author Gail Deyle, PT, DSc, DPT, OCS, FAAOMPT, a physical therapist and a senior faculty member of the Brooke Army Medical Center, San Antonio, tells Reuters Health in a telephone interview.
Although both treatments are common, theres been debate about which is the most effective and little good data on which should be tried first. Yet theres also been a trend away from physical therapy, at least since 2007, the researchers said.
Only about 10% of patients are offered any form of physical therapy prior to getting a total knee replacement, says Dr. Deyle, who is also a professor at Baylor University Graduate School.
You Are Told To Have A Cortisone Injection Is Prolotherapy An Option
In this video, Danielle R. Steilen-Matias, MMS, PA-C, Caring Medical gives a brief explanation of the differences between Prolotherapy and Cortisone
- The difference between Prolotherapy and Cortisone is extensive.
- Cortisone when injected into the joint can successfully mask pain. Many people have very successful treatments with Cortisone. We typically see patients who have a long history of Cortisone injection and these injections are no longer effective for them.
- Cortisone has been shown, in many studies, to accelerate degenerative osteoarthritis through cartilage breakdown.
- Over the years we have seen many patients who have received corticosteroid injections for joint pain. Unfortunately for many, excessive cortisone treatments lead to a worsening of chronic pain. Again, while some people do benefit from cortisone in the short-term the evidence however points to cortisone causing more problems than it helps.
This chart demonstrates that cortisone injections, acting as an anti-inflammatory, decreases circulation and repair to damaged joints as its primary means to reduce pain. Prolotherapy injections are shown to act in a different way, by repairing joint damage, Prolotherapy can reduce inflammation by repairing the damage causing the inflammation.
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A Direct Correlation Between Increased Steroid Concentration And Increased Chondrocyte Apoptosis
It becomes perplexing then, that these medications continue to be routinely injected into peoples joints therapeutically for pain. While corticosteroid and analgesic injections have the potential to temporarily relieve pain by shutting down the bodys inflammatory mechanisms, these medications are toxic to cartilage cells. Results of bovine cartilage studies from the University of Pittsburgh School of Medicine revealed the following:
A direct correlation between increased steroid concentration and increased chondrocyte apoptosis as well as increased chondrocyte toxicity with increasing time of exposure to methylprednisolone. The addition of lidocaine to methylprednisolone significantly increased the rate of chondrocyte cell death.
In the American Journal of Sports Medicine, university medical researchers in Japan demonstrated a case history in which a patient received high-dose cortisone treatments for a case of Bells Palsy, the same patient was also a volunteer subject in a study to test a stem cell-based Tissue Engineered Construct for cartilage and bone defect. Stem cells were harvested from the patient to build a scaffold patch.
- At three weeks after the cortisone treatment, the patients stem cells could not help generate the construct needed for the cartilage/bone patch.
- At seven weeks after steroid therapy the stem cells could, the stem cells had successfully withstood a direct attack from the cortisone, but it did take 7 weeks to recover.
What Is The Outlook For People After Cortisone Shots
It can take up to 7 days for a cortisone injection to begin working in the body. The effects of the injection usually last up to 2 months, but sometimes longer.
Cortisone can reduce inflammation that damages joints. Your doctor also may recommend other treatments to address joint pain resulting from another condition such as obesity, tendon or ligament damage, or an autoimmune disorder.
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What Are Complications Or Side Effects Of Cortisone Shots
Cortisone can weaken the immune system. For this reason, many doctors limit injections to once every 3 months for a specific joint, and 6 times a year for the entire body.
Cortisone can also raise blood sugar levels in people with diabetes. Doctors monitor blood sugar levels to make sure they are stable before delivering a cortisone injection. Cortisone may also cause osteoporosis , fluid retention , high blood pressure, and alterations in mood.
Patients who take other corticosteroid medication such as prednisone pills or inhaled steroids should get fewer injections or lower doses if possible to minimize the above risks.
All injections have a risk of infection. For this reason, it is important to keep the injection site clean.